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J. Electromagn. Eng. Sci > Volume 15(3); 2015 > Article
Journal of Electromagnetic Engineering and Science 2015;15(3):123-128.
DOI: https://doi.org/10.5515/JKIEES.2015.15.3.123   
Effects of 60-Hz Magnetic Fields on DNA Damage Responses in HT22 Mouse Hippocampal Cell Lines
Gil-Im Mun1, Seungwoo Lee2, Nam Kim2, Yun-Sil Lee1
1Graduate School of Pharmaceutical Sciences, Ewha Womans University
2School of Information and Communication Engineering, Chungbuk National University
Previously, we investigated extremely low-frequency magnetic fields (ELF-MFs) on diverse DNA damage responses, such as phosphorylated H2AX (${gamma}H2AX$), comet tail moments, and aneuploidy production in several non-tumorigenic epithelial or fibroblast cell lines. However, the effect of ELF-MF on DNA damage responses in neuronal cells may not be well evaluated. Here, we investigated the effects of ELF-MF on the DNA damage responses in HT22 non-tumorigenic mouse neuronal cells. Exposure to a 60-Hz, 2 mT ELF-MF did not produce any increased ${gamma}H2AX$ expression, comet tail moments, or aneuploidy formation. However, 2 mT ELF-MF transiently increased the cell number. From the results, ELF-MF could affect the DNA damage responses differently, depending on the cell lines.
Key words: Aneuploidy, Cell Lines, Comet Tail, Extremely Low Frequency, ${\gamma}H2AX$


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